這是本國際期刊的主要目的是成為一個多學科論壇的出版物，從所有領域的口腔醫學。特別是它的目的是在基礎科學和臨床科學之間建立聯系，從而促進信息交流和口腔醫學的進步，造福于患者。臨床口腔研究發表原創的科學文章，并邀請國際讀者對口腔頜面科學和醫學領域的基礎和臨床研究的最新結果進行評論，以澄清這些結果與現代實踐的相關性。涵蓋的課題有:頜面及口腔外科修復學、牙列外科、牙列外科、牙列牙髓學、牙周學、正畸學、牙科材料學、臨床試驗、流行病學、牙根學、口腔種植學、預防牙列學、口腔病理學、口腔基礎科學。一般不鼓勵提交病例報告。動物實驗的報告必須說明“實驗動物護理原則”(國立衛生研究院1985年修訂本第86-23號出版物)以及適用的具體國家法律(例如德國現行的動物保護法)均得到遵守。編輯有權拒絕不符合上述要求的稿件。如有虛假陳述或不符合上述要求，作者將承擔責任。

It is the primary aim of this international journal to be a multidisciplinary forum for publications from all fields of oral medicine. Especially it is intended to create a connection between basic and clinical sciences and thus promote the exchange of information and the advancement of oral medicine for the benefit of patients. Clinical Oral Investigations publishes original scientific articles and invited reviews which provide an international readership with up-to-date results of basic and clinical studies in the field of oral and maxillofacial science and medicine and to clarify the relevance of these results for a modern practice. Covered topics are: Maxillofacial and Oral Surgery Prosthetics and Restorative Dentistry Operative Dentistry Endodontics Periodontology Orthodontics Dental Materials Science Clinical Trials Epidemiology Pedodontics Oral Implant Preventive Dentistiry Oral Pathology Oral Basic Sciences. The submission of Case Reports is generally discouraged. Reports of animal experiments must state that the "Principles of laboratory animal care" (NIH publication No. 86-23 revised 1985) were followed as well as specific national laws (e.g. the current version of the German Law on the Protection of Animals) where applicable. The editor reserves the right to reject manuscripts that do not comply with the above-mentioned requirements. The author will be held responsible for false statements or for failure to fulfill the above-mentioned requirements.