該雜志邀請評論關于化學物質與生物系統相互作用的原始論文。藥理學和治療學的所有方面都是適當的，但是沒有劑量反應或機制研究的描述性病例報告是不能接受的。只有在提供數據表明使用新方法獲得了新的或更可靠的藥理信息時，才會審查主要涉及新方法的手稿。

The Journal invites for review original papers dealing with interactions of chemicals with biological systems. All aspects of pharmacology and therapeutics are appropriate, but descriptive case reports without dose-response or mechanistic studies are not acceptable. Manuscripts dealing primarily with new methods will be reviewed only if data are presented showing that new or more reliable pharmacological information has been obtained with their use.