該雜志邀請審閱有關化學物質與生物系統相互作用的原始論文。藥理學和治療學的各個方面都是適當的，但是沒有劑量反應或機械研究的描述性病例報告是不可接受的。主要涉及新方法的手稿只有在有數據表明通過使用獲得了新的或更可靠的藥理學信息的情況下才會被審查。

The Journal invites for review original papers dealing with interactions of chemicals with biological systems. All aspects of pharmacology and therapeutics are appropriate, but descriptive case reports without dose-response or mechanistic studies are not acceptable. Manuscripts dealing primarily with new methods will be reviewed only if data are presented showing that new or more reliable pharmacological information has been obtained with their use.