毒理學和應用藥理學發表了有關對動物或人類施用化學品、藥物或天然產品對組織結構或功能的作用的原始科學研究。文章論述了生理、生化、細胞或分子理解毒理學/病理損傷的機械方法，以及描述這些反應的方法。鼓勵發表與實驗動物使用替代品有關的論文。

Toxicology and Applied Pharmacology publishes original scientific research pertaining to action on tissue structure or function resulting from administration of chemicals, drugs, or natural products to animals or humans. Articles address mechanistic approaches to physiological, biochemical, cellular, or molecular understanding of toxicologic/pathologic lesions and to methods used to describe these responses. Papers concerned with alternatives to the use of experimental animals are encouraged.